A central focus of the group is the role of the ENS in neurodegenerative diseases. Here, i.e. it could be shown that the ENS also affects the intestinal nervous system in a disease that tends to affect cognitive abilities, such as Alzheimer's disease. In an animal model, changes in the ENS were observed long before changes in the CNS5. This also
AGENS
The Enteric Nervous System Research Group (AGENS) headed by Prof. KH Schäfer (HS KL) has been working for years on the characterization of the ENS in the context of development, changes in disease patterns, or the use of the enteric neural stem cells contained in it.1,2 First indications of an influence of local inflammation on these neural
1 Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.Sci Rep. 2015 Mar 20;5:9226. doi: 10.1038/srep09226. 2 Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic sig
1Schuck F, Wolf D, Fellgiebel A, Endres K. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. J Alzheimers Dis. 2016;50(3):817-26. doi: 10.3233/JAD-150737. 2Anna Wierczeiko, David Fournier, Hristo Todorov, Susanne Klingenberg, Kristina Endres, Susanne Gerber; Decoupling of DNA Methylation Status and Gene Expression Leve
The possibility of always being able to work independently on a project based on the cutting edge of research, as well as the joint discussion and exchange within the research group, is something I really enjoy about scientific work.
Motivation for my scientific work
Participation in the "ENS Development Meeting 5th International Symposium" - Boston, Massachusetts
Poster presentation on cryopreservation of enteric neurospheres.
Previous publications, posters, lectures, congress participation
Title: Establishment of an innervated, in vivo equivalent 3D co-culture model of the intestinal mucosa
Content: The functions of the gastrointestinal tract, such as food transport, digestion and regional blood circulation, are regulated and controlled by the enteric nervous system (ENS). The ENS is not only exposed to the microbiome and food c
Title: Influence of different bacterial strains on the enteric nervous system
Content: The human microbiome is composed of a multitude of different bacteria. In this thesis we investigated the effects of individual bacterial strains, as part of the intestinal microbiome, on the enteric nervous system (ENS), or intestinal motility, as one of the
Modulation of the gastrointestinal neuroimmunological interaction by biological agents using the example of Alzheimer's/Parkinson's disease.
Topic of doctoral thesis
