Modulation of the gastrointestinal neuroimmunological interaction by biological agents using the example of Alzheimer's/Parkinson's disease.
Topic of doctoral thesis
Title: Influence of different bacterial strains on the enteric nervous system
Content: The human microbiome is composed of a multitude of different bacteria. In this thesis we investigated the effects of individual bacterial strains, as part of the intestinal microbiome, on the enteric nervous system (ENS), or intestinal motility, as one of the
Title: Establishment of an innervated, in vivo equivalent 3D co-culture model of the intestinal mucosa
Content: The functions of the gastrointestinal tract, such as food transport, digestion and regional blood circulation, are regulated and controlled by the enteric nervous system (ENS). The ENS is not only exposed to the microbiome and food c
Participation in the "ENS Development Meeting 5th International Symposium" - Boston, Massachusetts
Poster presentation on cryopreservation of enteric neurospheres.
Previous publications, posters, lectures, congress participation
The possibility of always being able to work independently on a project based on the cutting edge of research, as well as the joint discussion and exchange within the research group, is something I really enjoy about scientific work.
Motivation for my scientific work
1Schuck F, Wolf D, Fellgiebel A, Endres K. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. J Alzheimers Dis. 2016;50(3):817-26. doi: 10.3233/JAD-150737. 2Anna Wierczeiko, David Fournier, Hristo Todorov, Susanne Klingenberg, Kristina Endres, Susanne Gerber; Decoupling of DNA Methylation Status and Gene Expression Leve
1 Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.Sci Rep. 2015 Mar 20;5:9226. doi: 10.1038/srep09226. 2 Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic sig
