Current activity:
| 2011-current | University Professor (W3) of Pharmaceutical and Medicinal Chemistry, Institute for Pharmaceutical and Biomedical Sciences (IPBW), Department 09, Chemistry, Pharmacy, Geography and Earth Sciences, Johannes Gutenberg- University Mainz |
Academic Education:
1999 | Appointment as private lecturer in Pharmaceutical Chemistry |
| 1993 - 1999 | Habilitation in Pharmaceutical Chemistry at the Pharmaceutical Institute of the Albert-Ludwigs-University Freiburg, Synthesis, In vitro testing and structure-activity correlations of new peptidic cysteine protease inhibitors: The importance of Aziridine dicarboxylic acid building blocks, Mentor Prof. Dr. A.-W. Frahm |
| 1993 | PhD (Dr. rer. nat.) (magna cum laude), Specialisation: Pharmaceutical Chemistry, Faculty for Chemistry and Pharmacy, Albert-Ludwigs-University Freiburg. |
| 1989 - 1993 | PhD thesis Enzymatic Hydrolysis of E/Z-diastereotopic Diesters and E/Z-diastereomers monoesters at the Pharmaceutical Institute of the University Freiburg with Prof. Dr. H.-H. Otto. |
| 1988 | Licence to practise pharmacy |
| 1987 - 1988 | Pharmacy practical training Bären-Apotheke, March |
| 1982 - 1987 | Pharmacy studies, Albert-Ludwigs-University Freiburg |
Former Activities:
| 2000 - 2011 | University Professor (C3) for Pharmaceutical and Medicinal Chemistry at the Institute for Pharmacy and Food Chemistry at the University Würzburg |
| 2000 | University lecturer (C2) at the Pharmaceutical Institute of the University Freiburg |
| 1999 - 2002 | Various lectureships at the Pharmaceutical Institute of the University of Freiburg and at the Pharmaceutical-Chemical Institute of the University of Heidelberg |
| 1993 - 1999 | Scientific Assistant (C1) at the Pharmaceutical Chemistry Institute with Prof. Dr. H.-H. Otto and after his calling to Greifswald with Prof. Dr. A.-W. Frahm, Pharmaceutical Institute of the University Freiburg |
| 1989 - 1993 | Scientific staff member at the Pharmaceutical Chemistry Institute with Prof. Dr. H.- H. Otto, Pharmaceutical Institute of the Albert-Ludwigs-University Freiburg |
Awards and Honors:
| 2017 | Literature Prize of the Chemical Industry Fund for the course book „Beyer/Walter, Organische Chemie“ with C. Schmuck and P. Wich |
| 1999 | Research award „Eugen-Graetz-Stiftung" of the University Freiburg for the dissertation |
| 1998 | Habilitation Award of the Division of Medicinal Chemistry of the GDCh and the Division of Pharmaceutical Chemistry of the DPhG |
| 1993 | Carl-Wilhelm-Scheele-Award of the German Pharmaceutical Society DPhG for the Dissertation |
Former Activities:
| 2020 - current | Vice Dean of FB 09 Chemistry, Pharmacy, Geography and Geosciences of the JGU Mainz |
| 2020 - current | Head of the B-Committee (Finances) of FB09 Chemistry, Pharmacy, Geography and Geosciences of the JGU Mainz |
| 2018 - current | Member of the Faculty Council of FB09 Chemistry, Pharmacy, Geography and Geosciences of the JGU Mainz |
| 2017 - current | Member of the Audit and Review Commissions (Subjects Analytics and Chemistry) at the Institute for Medical and Pharmaceutical Testing Questions (IMPP) Mainz |
| 2016 - current | Member of the Expert Commission on "General, Inorganic and Organic Chemistry" at the Institute for Medical and Pharmaceutical Testing Questions (IMPP) Mainz |
| 2015 - heute | Chairwoman of the Audit Committee State Examination Pharmacy |
| 2018 - 2021 | Chairwoman of the Pharmacy Study Committee |
| 2015 - 2021 | Chairwoman of the A2 Committee (Studies and Teaching) Pharmacy |
| 2015 - 2021 | Executive Director of the Institute for Pharmaceutical and Biomedical Sciences (IPBW) |
| 2015 - 2021 | Deputy Chairwoman of the Apotheker-Jacob-Stiftung |
| 2017 - 2020 | Member of the Governing Board of the Gutenberg Lectureship College GLK |
| 2013 - 2020 | Chairwoman of the Prof.-Rochelmeyer-Stiftung |
| 2015 - 2018 | Member of the Selection Committee of FB 09 for the German National Academic Foundation |
| 2004 - 2016 | Member of the Expert Commission "Pharmaceutical Analysis" at the Institute for Medical and Pharmaceutical Examination Questions (IMPP) Mainz |
| 2010 - 2011 | Chairwoman of the DPhG local group Würzburg |
Patents (granted):
C. Schmuck, K. Baumann, S. Rohrer, S. Langolf, U. Machon, T. Schirmeister; N-geschützte Guanidinsubstituierte Heteroaromaten als neue Cystein-Protease-Inhibitoren (103.193-3/08); Guanidinocarbonylpyrrole als neue Cystein-Protease-Inhibitoren (103.193-2/08). Deutsche Patentanmeldung DE 10 2008 049 767.3 (29.7.2009). N-geschützte Guanidin-substituierte Furane, Thiophene und Pyrrole als Cystein-Protease-Inhibitoren, 30.09.2009, WO 2010/037536 A1.
Topic specific publications (with Peer Review)
1. A. Welker, C. Kersten, C. Müller, R. Madhugiri, C. Zimmer, P. Müller, R. Zimmermann, S. Hammerschmidt, H. Maus, J. Ziebuhr, C. Sotriffer, T. Schirmeister, SAR of novel benzamides and isoindolines, designed as SARS-CoV protease inhibitors – effective against SARS-CoV-2. ChemMedChem 2021, 16, 340-354, Cover page, doi: 10.1002/cmdc.202000548; IF: 3.124.
2. P. Johe, S. Jung, E. Endres, C. Kersten, C. Zimmer, W. Xe, C. Sönnichsen, U. A. Hellmich, C. Sotriffer, T. Schirmeister*, H. Neuweiler*, Warhead reactivity limits the speed of covalent inhibition of the cysteine protease rhodesain. ACS Chemical Biology 2021, 16, 661-670, doi: 10.1021/acschembio.0c00911. IF: 4.434.
3. P. Johe, E. Jaenicke, H. Neuweiler, T. Schirmeister, C. Kersten*, U. A. Hellmich*; Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. J. Biol. Chem. 2021, 296, 100565, doi:10.1016/j.jbc.2021.100565 . IF: 4.238.
4. F. Barthels, G. Marincola, T. Marciniak, M. Konhäuser, S. Hammerschmidt, J. Bierlmeier, U. Distler, P. R. Wich, S. Tenzer, D. Schwarzer, W. Ziebuhr, T. Schirmeister, Asymmetric disulfanylbenzamides as irreversible and selective inhibitors of Staphylococcus aureus Sortase A. ChemMedChem 2020, 15, 839-850, doi: 10.1002/cmdc.201900687. IF: 3.124.
5. B. Millies, F. v. Hammerstein, A. Gellert, S. Hammerschmidt, F. Barthels, U. Göppel, M. Immerheiser, F. Elgner, N. Jung, M. Basic, C. Kersten, W. Kiefer, J. Bodem, E. Hildt, M. Windbergs, U. A. Hellmich, T. Schirmeister, Proline-based allosteric inhibitors of Zika and Dengue NS2B/NS3 proteases. J. Med. Chem. 2019, 62, 11359-11382, doi: 10.1021/acs.jmedchem.9b01697. IF: 6.205
6. M. Giroud, U. Dietzel, L. Anselm, D. Banner, J.-B. Blanc, D. Gaufreteau, H. Liu, A. Stich, B. Kuhn, F. Schuler, M. Kaiser, R. Brun, T. Schirmeister, C. Kisker, F. Diederich, W. Haap, Repurposing a human cathepsin L inhibitors library: Identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors, J. Med. Chem. 2018, 61, 3350-3369. doi:1021/acs.jmedchem.7b01869. IF: 6.205.
7. M. Giroud, B. Kuhn, S. Saint-Auret, C. Kuratli, R. E. Martin, F. Schuler, F. Diederich, M. Kaiser, R. Brun, T. Schirmeister,* W. Haap*, 2H-1,2,3-Triazole-based dipeptidyl nitriles: potent, selective and trypanocidal rhodesain inhibitors by structure-based design. J. Med. Chem. 2018, 61, 3370-3388. doi: 10.1021/acs.jmedchem.7b01870. IF: 6.205.
8. B. Kuhn, M. Tichý, L. Wang, S. Robinson, R. Martin, A. Kuglstatter, J. Benz, M. Giroud, T. Schirmeister, R. Abel, F. Diederich, J. Hert, Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors. J. Med. Chem. 2017, 60, 2485-2497. doi: 10.1021/acs.jmedchem.6b01881. IF: 6.205.
9. T. Schirmeister*, J. Kesselring, S. Jung, T. Schneider, A. Weickert, J. Becker, W. Lee, D. Bamberger, P. Wich, U. Distler, S. Tenzer, P. Johé, U. A. Hellmich, B. Engels*, Quantum chemicalbased protocol for the rational design of covalent inhibitors. J. Am. Chem. Soc. 2016, 138, 8332-8335. doi: 10.1021/jacs.6b03052. IF: 14.612
10. H. Wu, S. Bock, M. Snitko, T. Berger, T. Weidner, S. Holloway, M. Kanitz, W. E. Diederich, H. Steuber, C. Walter, D. Hofmann, B. Weißbrich, R. Spannaus, E. G. Acosta, R. Bartenschlager, B. Engels, T. Schirmeister,* J. Bodem, Novel Dengue virus NS2B/NS3 protease inhibitors. Antimicrob. Agents Chemother. 2015, 59, 1100-1109. doi: 10.1128/AAC.03543-14. IF: 4.715