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Patents
Method of treating or preventing central nervous system disorders using 1-ar(alk)ylimidazolin-2-ones; AKZ: 29900P, US 60/486678.
In Anmeldung beim Deutschen Patent- und Markenamt: „Kulturfreie Nutzung von Microelectrode-Arrays zur Ableitung erregbarer Zellen in vitro: Upside-Down MEA in Single and Co-culture Modus.“ Erfinder: Prof. K-H Schäfer, Dr. rer. nat. Holger Rabe und Dipl. Ing. Sebastian Schlüter.
Contact
![HSKL](/fileadmin/import/personen/3982_resized.jpg)
Studiengangsleitung "Applied Life Sciences, Master", Vorsitz Prüfungsausschuss: "Applied Life Sciences, Bachelor" "Applied Life Sciences, Master" "Biomedical Micro Engineering, Bachelor" "Micro- and Nanoengineering, Bachelor" "Micro Systems and Nano Technologies, Master" "Mikrosystem- und Nanotechnologie, Bachelor" "Physician Assistant, Bachelor" " Systems Engineering for Micro-Electro-Mechanical-Systems or Biomedical Micro Engineering, Master", Fachbereichsrat IMST, Fachausschuss Studium und Lehre MST, Fachkommission IMST Bachelor MBW FB IMST, Prüfungsausschuss ALS/BME/MNE/MNT Bachelor FB IMST, Prüfungsausschuss ALS/MNT Master FB IMST, Prüfungsausschuss Bachelor MBW FB IMST
- +49 631 3724-5423holger.rabe(at)hs-kl(dot)de
- Campus Zweibrücken
- Room H143
Most important congress contributions of the last years
11th International Meeting on Substrate-Integrated Microelectrode Arrays; July 2018
Decker, D., Pirrung, M., Gries, M., Ingebrandt, S., Schäfer, K-H., Saumer, M., Rabe, H.. Impedance of 3D Nanostructured MEAs: Influence of Coating and Cell Cultivation
European Neurogastroenterology meetings – NeuroGASTRO 2017
Clasohm, J., Ull-Sopha1, S., Stoye, N., Endres, K., Rabe, H., Schäfer, K-H.. Functional compensation of gastro intestinal motility indicates enteric plasticity in an early onset model of Alzheimer’s Disease.
Biosensors 2014
Rabe, H., Braun, A., Grimm, M., Hartmann, T., Schäfer, KH.. Using MEA technology for pharmacological screenings in Alzheimer’s disease.
Schwartz, L., Rabe, H., Grundmann, D., Schäfer, KH.. MEA recordings from myenteric plexus in vitro depend on the culture mode.
International Conference in Advanced Manufacturing for Multifunctional Miniaturised Devices (M6)
2013: H. Rabe, A. Braun, K-H. Schäfer. Does the biological nanoparticle, the amyloid ß peptide, influence directly the enteric nervous system?
2015: D. Decker, H. Rabe, M. Saumer. Development of 3D-nanostructured electrodes for biosensing applications
Neuroscience meeting
2014: Rabe, H., Braun, A., Grimm, M., Hartmann, T., Schäfer, KH. Acute effects of amyloid beta 42 on the GUT enteric nervous System (ENS)
Publications
Peer Reviewed
Schulte, Steven; Decker, Dominique; Nowduri, Bharat; Gries, Manuela; Christmann, Anne; Meyszner, Antoine; Rabe, Holger; Saumer, Monika; Schäfer, Karl-Herbert. (2024). Improving morphological and functional properties of enteric neuronal networks in vitro using a novel upside-down culture approach. American journal of physiology. Gastrointestinal and liver physiology. doi.org/10.1152/ajpgi.00170.2023.
Nowduri, Bharat; Schulte, Steven; Jolfaei, Negin Adavoudi; Decker, Dominique; Rabe, Holger; Schäfer, Karl-Herbert; Saumer, Monika, Advanced Biomimetic Nanostructured Microelectrode Arrays for Enhanced Extracellular Recordings of Enteric Neurons, Advanced Materials Interfaces. Bd. 10. H. 16. Wiley 2023. https://doi.org/10.1002/admi.202300023.
D. Decker, M. Pirrung, M. Gries, S. Ingebrandt, K.-H. Schäfer, M. Saumer, H. Rabe, Impedance Of 3D Nanostructured MEAs: Influence of Coating and Cell Cultivation, Front. Cell. Neurosci. 12 (2018). https://doi.org/10.3389/conf.fncel.2018.38.00094.
D. Decker, R. Hempelmann, H. Natter, M. Pirrung, H. Rabe, K.-H. Schäfer, M. Saumer, 3D Nanostructured Multielectrode Arrays: Fabrication, Electrochemical Characterization, and Evaluation of Cell-Electrode Adhesion, Adv. Mater. Technol. 4 (2018) 1800436. https://doi.org/10.1002/admt.201800436.
A. Schuster, H. Rabe, T. Schwab, M. Bischof, C. Degel, M. Klotz, K.-H. Schäfer, Neural stem cells influenced by ultrasound: Frequency and energy density dependencies, Phys. Med. 4 (2017) 8–16. https://doi.org/10.1016/j.phmed.2017.09.001.
H. Rabe, L. Schwarz, D. Grundmann, M. Weyland, K.-H. Schäfer, Multi-electrode-array (MEA) recordings from myenteric plexus in vitro dependent on the culture mode, Neurogastroenterol. Motil. 28 (2016) 53.
M. Gondre-Lewis, K. Warnock, H. Wang, H. June, K. Bell, H. Rabe, V.V.N.P.B. Tiruveedhula, J. Cook, H. Lüddens, L. Aurelian, Early life stress is a risk factor for excessive alcohol drinking and impulsivity in adults and is mediated via a CRF/GABAA mechanism, Stress. 19 (2016) 1–13. https://doi.org/10.3109/10253890.2016.1160280.
D. Grundmann, M. Klotz, W. Burkhard, S. Dominik, D. Simon, H. Rabe, H. Abdel-Aziz, O. Kelber, K.-H. Schäfer, Tu1443 Influences of STW 5, a Multi-Component Herbal Preparation, on Motility and Inflammation Challenges in Gut and Enteric Nervous System (ENS), Gastroenterology. 150 (2016) S905. https://doi.org/10.1016/S0016-5085(16)33066-9.
D. Dominique, I. Sven, H. Rabe, K.-H. Schäfer, M. Saumer, Fabrication Of 3D Nanostructured Multielectrode Arrays By Using Thermal Nanoimprint Lithography To Improve Cell Coupling For Low Signaling Neurons, Front. Neurosci. 10 (2016). https://doi.org/10.3389/conf.fnins.2016.93.00039.
D. Grundmann, M. Klotz, H. Rabe, M. Glanemann, K.-H. Schäfer, Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract, Sci. Rep. 5 (2015) 9226. https://doi.org/10.1038/srep09226.
S. Dominik, G. Erkel, M. Schäfer, L. Marx, M. Klotz, H. Rabe, M. Martin, K.-H. Schäfer, Checking novel antiinflammatory drugs on neuroinflammatory processes in the isolated enteric nervous system, Neurogastroenterol. Motil. 26 (2014) 38.
J. Ludwig, H. Rabe, Höffle-Maas, Samochocki, A. Maelicke, Kaletta, Directed Mutagenesis of Nicotinic Receptors to Investigate Receptor Function. In: Genetic Manipulation of DNA and Protein - Examples from Current Research. (Edited by David Figurski), Publisher InTech, ISBN 978-953-51-0994-5 (2013) https://doi.org/10.5772/50890.
E. Leppä, A.-M. Linden, H. Rabe, O. Vekovischeva, P. Wulff, H. Lüddens, W. Wisden, E. Korpi, Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation, Eur. J. Pharmacol. 666 (2011) 111–121. https://doi.org/10.1016/j.ejphar.2011.05.011.
M. Jansen, H. Rabe, A. Strehle, S. Dieler, F. Debus, G. Dannhardt, M. Akabas, H. Lüddens, Synthesis of GABAA Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site, J. Med. Chem. 51 (2008). https://doi.org/10.1021/jm701562x.
K. Hellsten, M. Ranna, H. Rabe, S. Sinkkonen, T. Möykkynen, M. Uusi-Oukari, A.-M. Linden, H. Lüddens, E. Korpi, Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic α6β GABAA receptors, J. Neurochem. 105 (2008) 338–350. doi.org/10.1111/j.1471-4159.2007.05136.x.
Dissertation
Rabe, Holger (1999): Untersuchungen zur Physiologie von Neuronen und radialen Gliazellen im Sehzentrum der Regenbogenforelle (Oncorhynchus mykiss).