Simone Eggert, PD Dr.
Research assistant at the University of Kaiserslautern
Contact: s.eggert[at]biologie.uni-kl.de
Biography:
| Since 2011 | Research assistant, Kins lab, TU Kaiserslautern, (Alzheimer's disease) |
| 2005 - 2010 | Post-doc, Koo lab, University of California, San Diego (UCSD), School of Medicine, USA, (Alzheimer´s disease) |
| 2004 - 2005 | Post-doc, Beyreuther lab, University of Heidelberg |
| 01.03.2023 | Rehabilitation at the University of Göttingen, Venia Legendi: Cell and Neurobiology |
| 06.07.2022 | Habilitation at the TU Kaiserslautern, Venia Legendi: Cell and Neurobiology |
| 2004 | PhD "The proteolytic processing of the APP gene family members APLP1 and APLP2" at the University of Heidelberg, Dr.rer.nat. (Alzheimer`s disease) |
| 1994 - 1999 | Study of Biology (Diploma) at the Ruprecht-Karls-Universität Heidelberg Diploma: January 2000 in the AG Beyreuther (Alzheimer's disease) |
Member of the German Association of Universities „Deutscher Hochschulverband“
Awards and Honors:
| 2020 | Representative of the Department of Biology in the Forum for Scientific Employees of the TU Kaiserslautern |
| 2020 | Research Award from the „Alzheimer Forschung Initiative“ (AFI) |
| 2008 | post-doctoral fellowship Ellison Medical Foundation / American Federation for Aging Research (AFAR), USA |
| 2007 | post-doctoral fellowship, DFG (German Research Foundation) |
| 2006 | post-doctoral fellowship, DFG (German Research Foundation) |
| 2003 | Boehringer-Ingelheim travel grant for a 3-month research stay at the University of Melbourne in the laboratory of Prof. Colin L. Masters |
| 2000 - 2003 | Doctoral scholarship of the Graduate College of Biotechnology, Heidelberg |
| 2000 | Award for Diploma thesis of the GFM "Society for the Promotion of Molecular Biological Research in Heidelberg" |
Topic specific publications
2022
1 Schilling, S., *Pradhan, A. *Heesch, A., Helbig, A., Blennow, K., Koch, C., Bertgen, L., Koo, E.H., Brinkmalm, G., Zetterberg, H., Kins, S.*.Eggert, S.* “Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity“, posted on research square 21.11.22, DOI: 10.21203/rs.3.rs-2293469/v1, Corresponding author
2 Schilling, S., August, A., Meleux, M., Conradt, C., Tremmel, L., Teigler, S., Adam, V., Koo, E.H., Kins, S., Eggert, S*. Title: „APP family member dimeric complexes are formed predominantly in synaptic compartments“ bioRxiv preprint doi: https://doi.org/10.1101/2022.09.13.507759; this version posted September 16, 2022, Corresponding author
3 Busch L, Eggert S, Endres K, Bufe B, The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease. Cells. 2022 Oct 29;11(21):3421. doi: 10.3390/cells11213421.PMID: 36359817 Free PMC article. Review (IF 2021: 6.7)
2021
4 Eggert, S., Kins, S., Endres, K., Brigadski, T., Brothers in arms: proBDNF/BDNF and sAPPα/Aβ signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer`s disease. Biol.Chem 2021 Oct 7;403(1):43-71. doi: 10.1515/hsz-2021-0330. Print 2022 Jan 26.PMID: 34619027 Review. Corresponding author
5 Witthohn, M., Strieth, D, Eggert, S., Kins., S, Ulber, R., Muffler, K. Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activityCurrent Research in Biotechnology, accepted 03.11.2021 Volume 3, 2021, Pages 281-287 https://doi.org/10.1016/j.crbiot.2021.10.002
6 Nguyen VTT, König S, Eggert S, Endres K, Kins S The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research. Biol Chem. 2021 Aug 27;403(1):3-26. doi: 10.1515/hsz-2021-0214. Print 2022 Jan 26.PMID: 34449171 Review.
2020
7 Endres, K and Eggert, S, Presentation of Scientific Institutions, “NeurodegX” Neuroforum (De Gruyter), 25.07.2020 https://doi.org/10.1515/nf-2020-0019, IF 2020: 0.21
8 Eggert, S.*, Grübl, T.*, Rupp, C., Sander, B., Heesch, A., Rajender, R., Zimmermann, M., Höpfner, S., Zentgraf, H., Kins, S.,The Rab5 activator RME-6 is required for Amyloid Precursor Protein (APP) endocytosis depending on the juxtamembranous YTSI motif, Cell Mol Life Sci 2020 Feb 17. doi: 10.1007/s00018-020-03467-1. [Epub ahead of print]
2018
9 Eggert, S., Kins, S., Thomas, C., Hermey, G, Trafficking in Alzheimer’s disease: odulation of APP transport and processing by the transmembrane proteins LRP1, SorLA, SorcS1c, Sortilin and Calsyntenin, Mol Neurobiol2018 Jul;55(7):5809-5829. doi: 10.1007/s12035-017-0806-x. Epub 2017 Oct 27. Review. Corresponding author
10 Eggert, S.,* Gonzalez, AC.,* Thomas, C., Schwarz, SM., Tischer, C., Schilling, S., Strecker, P., Schmidt, V., Willnow, TE., Hermey, G., Pietrzik, CU., Koo, EH, Kins, S. Dimerization leads to changes in APP (Amyloid Precursor Protein) trafficking mediated by LRP1 and SorLA, Journal of Cell Mol Life Sci2018 Jan;75(2):301-322. doi: 10.1007/s00018-017-2625-7. Epub 2017 Aug 10. PMID:28799085 Corresponding author