Karl-Herbert Schäfer, Prof., Dr. med

Professor of Biotechnology in Mikrosystemstechnology, University of Applied Sciences Kaiserslautern

   

 

HSKL

Vizepräsident für Forschung, Studiengangsleitung "Physician Assistant, Bachelor", Forschungsschwerpunkt Integrierte Miniaturisierte Systeme FB IMST, Projekt Charakterisierung enterischer neuronaler Stammzellen FB IMST, Projekt Darmfunktionsdiagnostik FB IMST, Projekt ImmENS, Interaktion des Mikrobioms mit dem Enterischen Nervensystem (ENS), Projekt Intrinsische Stammzellen FB IMST, Projekt Modifizierung und Anwendung von Multielektrodenarrays zur Erfassung neuraler Signale des ENS, Projekt Offene Digitalisierungsallianz für die Pfalz, AG ENS, Projekt Transplantation neuraler Stammzellen zur Behandlung von Aganglionosen, Projekt Untersuchungen der Darmmotalität und des Darmnervensystems im Kontekt neurodegenerativer Erkrankungen, Working Group Enteric Nervous System

Biography:

Since 2017 Vicepresident Research and Transfer University of Applied Sciences Kaiserslautern
  
06/2008 - 12/2008  Visiting Professor University Stanford, California, USA
09/2001Appointment C3-Professorship, Biotechnology,
University of Applied Sciences Kaiserslautern.
Head of Working Group Enteric Nervous System of Pediatric Surgery,
University Heidelberg, Hospital Mannheim
07/1999 - 09/1999

Research Resident, Department of Pediatric Surgery,
University Heidelberg, Hospital Mannheim

1995 - 1999Assistant Professor, Anatomy Homburg, Consultant in Anatomy 
1992 - 1993Research Sabbatical, University College London
1991 - 1995Research Assistant, Department of Anatomy Homburg
1990Specialisation in Emergeny Medicine
1988 - 1991Resident, Department of Surgery, St.Josef-Krankenhaus      
Neunkirchen
1987 - 1988Research Assistant, Department of Anatomy Homburg
  
2000Habilitation: „Isoliation and cultivation of myenteric plexus: a new approach to investigate the postnatal
development of the enteric nervous system in men and rat."
1993Doctoral Thesis "Morphology of GABA-ergic Neurones in the
medial preoptic nucleus (MPN) of the rat"
1980 - 1986Study of human medicine at the University of Saarland, Homburg
Approbation Oktober 1986

    Member of Society for Neurosciences, Anatomical Society Germany, Neurogastroenterology and Motility Society Germany,
    International Society for Autonomous Neurosciences, Sout-West-Germany SAR Medical Doctor Assocication, German Society of Stem Cell Researh

    Awards and Honors:

    • Martin-Wienbeck Award 2014
    • Novartis Award, Experimental Pediatric Surgery Symposium Graz, 2003
    • Nomination Soave Award of the Colorectal Club, Stockholm1999
    • Multiple Posterawards

    Topic specific publications

    1   Endres K and Schäfer KH. Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases. Journal of Innate Immunity. 2018 May 9:1-9. doi: 10.1159/000488629.

    2   Schwiertz A, Spiegel J, Dillmann U, Grundmann D, Bürmann J, Faßbender K, Schäfer KH, Unger MM. Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism and Related Disorders. 2018 doi: 10.1016/j.parkreldis.2018.02.022.

    3   Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer KH. Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitroModels. Frontiers in Physiology. 2017 Aug 7;8:566. doi: 10.3389/fphys.2017.00566. eCollection 2017.

    4   Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K. Altered  Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model. J Alzheimers Disease. 2017;56(2):775-788. doi: 10.3233/JAD-160926.

    5   Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, Faßbender K, Schwiertz A, Schäfer KH. Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism and Related Disorders. 2016 Aug 26. pii: S1353-8020(16)30323-6. doi: 10.1016/j.parkreldis.2016.08.019.

    6   Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH et al.. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology. 2016 Apr 5. pii: S0012-1606(16)30111-7. doi: 10.1016/j.ydbio.2016.04.001.

    7   Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.    
    Scientific  Report
    . 2015 Mar 20;5:9226. doi: 10.1038/srep09226.

    8   Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, Martin M, Nguyen TD, Nguyen TNQ, Gries M, Faßbender K, Conconi MT, Parnigotto PP, Schäfer KH. Maintenance of the enteric neural stem cell niche by bacterial Lipopolysaccharides, Journal of Cellular and Molecular Medicine, 2014, doi: 10.1111/jcmm.12292.

    9   Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. Changes of the enteric nervous system in Amyloid Precursor Protein transgenic mice correlate with disease progression. Journal of Alzheimers Disease, 2013, 36(1):7-20. doi: 10.3233/JAD-120511.

    10  Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals and hypersensitivity. Acta Neuropathologica. 2013. 125(4):491-509.