Kristina Endres, PD. Dr. rer. nat., Biochemistry Specialisation
Graduate Biologist, Head of Laboratory, Department of Psychiatry and Psychotherapy
Faculty of Medicine, Johannes Gutenberg-University Mainz
| Website | Research Group „Molecular Mechanisms of Healthy Ageing |
Current activity:
| 2009-current | Head of Laboratory, Department of Psychiatry and Psychotherapy, Faculty of Medicine, Johannes Gutenberg-University Mainz |
Academic Education:
2014 | Venia Legendi Faculty of Chemistry, Pharmacy and Geology |
| 2005 | PhD (Dr. rer. nat. magna cum laude) at the Faculty of Chemistry, Johannes Gutenberg-University Mainz |
| 2001 - 2005 | PhD „Proteolysis of the amyloid precursor protein-related APLP2. by α-secretases: Functional significance in differentiation and apoptosis“ at Institute for Biochemistry, Johannes Gutenberg-University Mainz, with Prof. Dr. Dr. hc. Falk Fahrenholz |
| 1997 | Diploma (with Award), Faculty of Biology of the Johannes Gutenberg-University Mainz |
Former Activities:
| 2008 - 2009 | PostDoc in the research group of Dr. Rolf Postina, Institute of Biochemistry, Therapeutic Life Sciences, Johannes Gutenberg-University, Mainz |
| 2005 - 2008 | PostDoc in the research group of Prof. Dr. Dr. hc Falk Fahrenholz, Institute of Biochemistry, Johannes Gutenberg-University, Mainz |
| 1993 - 1996 | Biology lab assistant, Hoechst AG, Frankfurt/ Main |
Awards and Honors:
| 2015 | Hans-Jörg Weitbrecht Science Award |
| 2006 | Award for young scientists 2006 of the IFZN (Interdisciplinary Research Centre for Neurosciences) for excellent doctorate, Mainz |
| 2000 - 2001 | Sponsorship scholarship of Johannes Gutenberg-University Mainz |
Topic specific publications (withPeer Review)
1. Valeri F, Endres K. How biological sex of the host shapes its gut microbiota Front Neuroendocrinol. 2021 Mar 10;61:100912. doi: 10.1016/j.yfrne.2021.100912. IF 9,06
2. Nguyen,VTT, Sallbach, J, dos Santos Guilherme,M, Endres, K. Influence of Acetylcholine Esterase Inhibitors and Memantine, Clinically Approved for Alzheimer’s Dementia Treatment, on Intestinal Properties of the Mouse. Int. J. Mol. Sci. 2021, 22(3), 1015; doi: 10.3390/ijms22031015 - 20 Jan 2021. IF 4,56
3. Stoye N.M., dos Santos Guilherme M., Endres K. Alzheimer’s disease in the gut – major changes in the gut of 5xFAD model mice with ApoA1 as potential key player. FASEB J 2020. IF 4,97; doi: 10.1096/fj.201903128RR
4. Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF. NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. EMBO Mol Med. 2019 Apr;11(4). pii: e9695. doi: 10.15252/emmm.201809695. IF 10,62
5. Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K.Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease. Cell Mol Life Sci. 2019 Mar;76(5):1005-1025. doi: 10.1007/s00018-018-2998-2. Epub 2019 Jan 1. IF 7,01
6. Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, Endres K. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018. IF 4,01; doi: 10.1038/s41598-018-19577-7
7. Endres, K, Deller, T. Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms. FRONTIERS IN MOLECULAR NEUROSCIENCE Volume: 10 Article Number: 56 Published: MAR 17 2017, IF 5,08; doi: 10.1016/j.biopha.2019.108661
8. Endres K, Fahrenholz F, Lotz J, Hiemke C, Teipel S, Lieb K, Tüscher O, Fellgiebel A. Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin. Neurology. 2014 Nov 18;83(21):1930-5. doi: 10.1212/WNL.0000000000001017. IF 8,3
9. Sakry, D, Neitz, A, Singh, J, Frischknecht, R, Marongiu, D, Binamé, F, Walmsley-Perera, S, Endres,K, Lutz, B, Radyushkin, K, Trotter, J, Mittmann, T. OPC modulate the neuronal network via activity-dependent ectodomain cleavage of glial NG2. PLOS Biology November 2014 vol. 12 issue: 11. IF 11,8; doi: 10.1371%2Fjournal.pbio.1001993
10. Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van LF, Fahrenholz F. A disintegrinmetalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 2004;113(10):1456-64. IF 15,43; doi: 10.1172%2FJCI20864