Bufe Bernd, Prof. Dr. rer. nat., Molecular Biology

Professor (W2) for Molecular Immunology & Immunosensors, University of Applied Science Kaiserslautern

Faculty of Computer Science and Microsystems Engineering (IMST)

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HSKL

Dekan FB IMST, Fachbereichsrat IMST, Fachkommission IMST Bachelor MBW FB IMST, Prüfungsausschuss Bachelor MBW FB IMST

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Current activity:

2017 - current     Professor (W2) of Molecular Immunology & Immunosensors,
Faculty of Computer Science and Microsystems Engineering (IMST), University of Applied Science Kaiserslautern

 

Academic Education:

2003         PhD (Dr. rer. nat.) (magna cum laude) in Mathematics and Natural Sciences Faculty of the University of Potsdam.
1997 - 2003         PhD thesis Identification and characterisation of bitter receptors in the Department of Molecular Genetics,
at the German Institute of Human Nutrition (DIfE), Potsdam, with Prof. Dr. Wolfgang Meyerhof.
1997       Diploma ( excellent), Faculty of Mathematics and Natural Sciences of the University
Bayreuth.

 

Former Activities:

2011 - 2017Academic council, at the Center for Integrative Physiology and Molecular Medicine
(CIPMM), with Prof. Frank Zufallat at Saarland University Medical Center in Homburg.
 
2007 - 2011Project Manager in the Department of Molecular Neurobiology, with Prof. Frank Zufall
at the Institute of Physiology, at Saarland University Medical Center in Homburg.
2003 - 2007Postdoc in the Department of Molecular Genetics with Prof. Dr. W. Meyerhof,
at the German Institute of Human Nutrition (DIfE), in Potsdam.
1997 – 2003Research assistant in the Department of Molecular Genetics at Prof. Dr. W.
Meyerhof, at the German Institute of Human Nutrition (DIfE), in Potsdam.

 

Patents:

  1. Bufe B, Hofmann T, Krautwurst K, Kuhn C, Meyerhof W: Bitter taste receptors. US8709737B2.
    Filed: 2002, Issued: 2014.
  2. Bufe B, Meyerhof W, Kuhn C: Agonists of bitter taste receptors and uses thereof US8012701B2
    Filed: 2004 Issued: 2011
  3. Bufe B, Kuhn C, Meyerhof W: Antagonists of bitter taste receptors and uses thereof EP2137530B1.
    Filed: 2007 Issued: 2018
  4. Behrens M, Brockhoff A, Bufe B, Kuhn C, Meyerhof W, Winnig M: Agonisten eines Rezeptors mit
    bitterem Geschmack und ihre Verwendungen. EP1737442B1 Filed: 2004 Issued: 2015

Topic specific publications (withPeer Review)

1.  Perniss A.; Liu S.; Boonen B.; Keshavarz M.; Ruppert . A. L.; Timm T., Pfeil U.; Soultanova A.; Kusumakshi S.; Delventhal L.; Aydin Ö.; Pyrski M.; Deckmann K.; Hain T.; Schmidt N.; Ewers C.; Günther A.; Lochnit G.; Chubanov V.; Gudermann T.; Oberwinkler J.; Klein J.; Mikoshiba K.; Leinders-Zufall T.; Offermanns S.; Schütz B.; Boehm U.; Zufall F.; Bufe B.; Kummer W. Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity. 2020 14;52(4):683-699.e11. doi: 10.1016/j.immuni.2020.03.005. IF: 22,6.

2.  Bufe B.; Teuchert Y,: Schmid A.; Pyrski M.; Pérez-Gómez A.; Eisenbeis J.; Timm T.; Ishii T.; Lochnit G.; Bischoff M.; Mombaerts P.; Leinders-Zufall T.; Zufall F. Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nat Commun. 2019 25;10(1):4889. doi: 10.1038/s41467-019-12842-x. IF: 12,1.

3.  Blum T.; Moreno-Pérez A.; Pyrski M.; Bufe B.; Arifovic A.; Weissgerber P.; Freichel M.; Zufall F.; Leinders-Zufall T. Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus. Proc Natl Acad Sci U S A. 2019 116(30):15236-15243. doi: 10.1073/pnas.1905705116 .IF: 9,4.

4.  Stempel H.; Jung M.; Pérez-Gómez A.; Leinders-Zufall T.; Zufall F.; Bufe B. Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems. J Biol Chem. 2016 29;291(18):9762-75. doi: 10.1074/jbc.M116.714493. IF: 4,1.

5.  Bufe B.; Schumann T.; Kappl R.; Bogeski I.; Kummerow C.; Podgórska M.; Smola S.; Hoth M.; Zufall F. Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a newmechanism for sensing pathogens. J Biol Chem. 2015 20;290(12):7369-87. doi: 10.1074/jbc.M114.626747. IF: 4,4

6.  Bufe B.; Schumann T., Zufall F. Formyl peptide receptors from immune and vomeronasal system exhibit distinct agonist properties. J Biol Chem. 2012 28;287(40):33644-55. doi: 10.1074/jbc.M112.375774. IF: 5,2.

7.  Weiss J.; Pyrski M.; Jacobi E.; Bufe B.; Willnecker V.; Schick B., Zizzari P.; Gossage S. J.; Greer C.A.; Leinders-Zufall T.; Woods C. G.; Wood J. N.; Zufall F. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature. 2011 14;472(7342):186-90. doi: 10.1038/nature09975. IF: 24,5.

8.  Wooding S.; Bufe B.; Grassi C.; Howard M. T.; Stone A. C.; Vazquez M.; Dunn D. M.; Meyerhof W.; Weiss R. B.; Bamshad M. J. Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature. 2006 13;440(7086):930-4. doi: 10.1038/nature04655. IF: 15,6.

9.  Bufe B.; Breslin P. A.; Kuhn C.; Reed D. R,; Tharp C. D.; Slack J. P.; Kim .U. K.; Drayna D.; Meyerhof W. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 2005 22;15(4):322-7. doi: 10.1016/j.cub.2005.01.047. IF: 6,4.

10. Bufe B.; Hofmann T.; Krautwurst D.; Raguse J. D.; Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002 32(3):397-401. doi: 10.1038/ng1014. IF: 18,7.