The gastrointestinal microflora is gaining more and more attractivity concerning its influence upon a broad range of body functions and well being in generalIn this project we are investigating the interaction between individual bacteria and complex microflora with the enteric nervous system (ENS), and thus the gut functi-on, especially in neurodegenerative disorders.Motility measurements under the influence of specific bacteria, as well as co-cul-ture systems where enteric neurons and glials cells are cultured together with bacteria, are used.A specific focus will be laid on the responses of the ENS to microbiotal stimuli that may change the individual properties of both neurons and glial cells.